Rapamycin of MTOR Inhibitor
Delivery term:The date of payment from buyers deliver within days- Price:
Negotiable
- minimum:
- Total supply:
- Delivery term:
The date of payment from buyers deliver within days
- seat:
Beijing
- Validity to:
Long-term effective
- Last update:
2020-11-30 10:14
- Browse the number:
293
- MedChemHub By certification [File Integrity]
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Contact:
fengyy(Mr.)
- Email:
- Telephone:
- Phone:
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Area:
Beijing
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Address:
#201, Sheng Shi Da Sha, 3081 Qiao Xiao Road, Fu Tian District, Shen Zhen, China
- Website: http://www.medchemhub.com/ http://fengyy.drivedemons.com/
Product details
Research Only! We don’t sell for human use.
Rapamycin, also known as sirolimus or AY-22989, is a specific mTOR inhibitor and has potent immunosuppressive and antiproliferative properties. It is used in coating coronary stents, treatment of lung diseases such as lymphangioleiomyomatosis and preventing organ transplant rejection, especially useful for kidney transplant rejection. By reducing the sensitivity to interleukin-2 (IL-2) through mTOR inhibiting, rapamycin inhibits activation of T cells and B cells.
Cat. No. |
53123-88-9 |
Purity |
99.94% |
Target |
mTOR, Autophagy, Human Endogenous Metabolite |
IC50 |
0.1 nM (IC50, in HEK293 cells ) |
In Vitro |
Lung Cancer Cell Lines: A549, SPC-A-1, 95D and NCI-H446 |
In Vivo |
Animal Model: 24 male nu/nu mice, aged 4-5 week old, weighted 15-20g |
Formula |
C₅₁HH₇₉NO₁₃ |
SMILES |
O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](O)CC4)OC)C)=O)=O |
M. Weight |
914.2 |
Storage |
Powder: -20°C 3 years |
Solvent & Solubility |
|
Documentation |
Contact us for relevant PDF documents. |
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